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Two new benzolactones from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activities

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journal contribution
posted on 2015-12-17, 08:07 authored by Qinpeng Shen, Xingmeng Xu, Fengmei Zhang, Nengjun Xiang, Pei He, Xiaoxi Si, Ruizhi Zhu, Kunmiao Wang, Zhihua Liu, Chunbo Liu, Mingming Miao

Two new benzolactones, 5-methyl-6-prenyl-isobenzofuran-1(3H)-one (1), 5-hydroxymethyl-6-prenyl-isobenzofuran-1(3H)-one (2), together with four known phenolic compounds (3–6), were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–6 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1–6 exhibited high anti-TMV activities with inhibition rates in the range of 16.9–26.2%, respectively.