Triterpene-farnesyl hydroquinone conjugates from Ganoderma calidophilum

Two new lanostane-type triterpenoids characterized with farnesyl hydroquinone moieties, ganocalidoins A (1) and B (2), were isolated from the fruiting body of Ganoderma calidophilum, together with two known tripterpenes (3-4). The structures of compounds 1 and 2 were determined by extensive spectroscopic data including HRESIMS, 1D and 2D NMR. Ganocalidoins A and B showed anti-oxidant capacity with IC₅₀ values of 38.7 ± 2.8 and 34.2 ± 1.8 μM, respectively. The compounds did not show tyrosinase inhibition activity.