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Total Synthesis of Jerangolid D

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journal contribution
posted on 2007-03-28, 00:00 authored by Jiří Pospíšil, István E. Markó
A short and convergent synthesis of jerangolid D is described. As key steps, a Blaise reaction is employed to construct the lactone ring, a diastereoselective multicomponent Sakurai condensation leads to the dihydropyran ring, and the skipped diene is assembled using a modified Julia olefination.