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The role of ras gene in the development of haemic neoplasia in Mytilus trossulus
journal contribution
posted on 2024-10-11, 11:46 authored by C.M. Ciocan, J.D. Moore, Jeanette RotchellJeanette RotchellDisseminated neoplasia has been reported in mussels (Mytilus spp) from numerous locations worldwide. This condition is progressive and fatal and the aetiology is unknown. In vertebrates, oncogenes such as ras, and tumour suppressor genes such as p53, play important roles in carcinogenesis. We have cloned a Mytilus trossulus homologue of the vertebrate ras gene, which shows conserved sequence in regions of functional importance. Neoplastic hemolymph samples derived from M. trossulus have been investigated for the presence of ras gene mutations and changes in expression. © 2006 Elsevier Ltd. All rights reserved.
History
School affiliated with
- College of Health and Science (Research Outputs)
Publication Title
Marine Environmental ResearchVolume
62Issue
SUPPL. 1ISSN
1411136Date Accepted
2006-04-18Usage metrics
Categories
Keywords
AnimalsCloning, MolecularDNA PrimersGene Expression Regulation, NeoplasticGenes, rasHemocytesMolecular Sequence DataMytilusNeoplasmsPolymorphism, Single-Stranded ConformationalRNA, Ribosomal, 18SMytilus trossulusVertebrataGenetic engineeringGeographical regionsMutagenesisTumorsprotein p53aquatic communitycarcinogendiseaseetiologygenegene expressionmussel culturemutationtumorarticlecarcinogenesisgene mutationgene sequencehemolymphmolecular cloningmusselneoplasmnonhumannucleotide sequenceoncogene rassequence homologytumor suppressor genevertebrateDisseminated neoplasiasGene expressionsNeoplastic hemolymphOncogenesGenes
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