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The predicted viral load set-points for the treated macaques.

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journal contribution
posted on 09.06.2021, 17:33 by Chad R. Wells, Youfang Cao, David P. Durham, Siddappa N. Byrareddy, Aftab A. Ansari, Nancy H. Ruddle, Jeffrey P. Townsend, Alison P. Galvani, Alan S. Perelson

The viral load set points predicted by the model using the best-fit parameter estimates and the mechanism with the greatest AIC weight from A) and B) with the baseline cell source model; C) and D) the model with a saturated source of effector cells; E) and F) a model where the source of effector cells is dependent on the concentration of antigen presenting cells. The maximum and minimum viral load equilibrium points predicted by the model (left column) and estimated by the predicted viral load at 81 weeks p.i. (right column). Parameters for these simulations are in Tables 1 and S14S18, for the AIC selected mechanism (S5S12 Tables). We do not consider the alternative mechanism of increased antigen presentation with increased viral clearance in this analysis.