The percentages of the found and categorized non-coding SNPs provided by the RegulomeDB webserver.
journal contribution
posted on 2024-12-23, 18:41 authored by Bonoshree Sarkar, Muhammad Safiul Alam Mondal, Taibur Rahman, Md. Ismail Hosen, Atiqur RahmanSNPs in the (a) 3’ UTR region are categorized into 4 ranks - 2a (1%), 2b (18%), 3a (3%), and 4 (78%); in (b) intron region are categorized into 8 ranks– 1b (1%), 1f (0%), 2a (11%), 2b (14%), 2c (0%), 3a (2%), 4 (71%), and 5 (1%); and the SNPs in (c) 5’ UTR region are categorized into 2 ranks– 2b (10%) and 4 (90%).
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various human cellssolvent accessibility analysespredict potentially harmfuloffering valuable insightscreate new ones5 8242mostly annotated variantgene expression regulation3 8242xlink "> cxcr4mutated cxcr4 variantsligand binding affinitynatural ligand cxcr4potential functional consequencesh113p mutated proteinselevated rmsd valueschemokine receptor knownprotein binding regulationcoding snps basedconducted using tmassociated functional snpsligand bindingcxcr4 genecoding snpsmutant 3h113p variantrisk codingregulatory potentialpotential rolesfunctional impactvulnerable germvisualization aidedtools siftswis modelstructural analysisregulomedb databasesregulatory effectsreduced tmpyrx toolprotein stabilityprotein harboringpathogenic nssnpsouter membranemutant residuesmultiple pathologiesmolecular effectsmolecular dockingmodulator 1md simulationmay paveline missenseintronic regionsincluding leukocytesincluding cancershiv infectiongenetic variationdepth analysiscxcr genescomprehensive characterizationchromatin statecausing nssnps23 nssnps100 nanoseconds
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