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P38 MAPK inhibitor suppressed autophagy in cryopreserved valve cells.

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posted on 2018-03-09, 18:50 authored by Hongyan Wu, Qing Chang

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The cryoprotectant trehalose could inhibit ERS-induced apoptosis by activating autophagy in cryoprotected rat valves
PLOS ONEPLOS ONE

Categories

  • Biochemistry
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Physiology
  • Biotechnology
  • Chemical Sciences not elsewhere classified
  • Immunology
  • Biological Sciences not elsewhere classified
  • Cancer

Keywords

cryopreserved tissuevalve allograft storagecell structuresCCAATdimethyl sulphoxidecell activitieshealth problemscryoprotected rat valves Valvular diseasesstress responsesp 38 MAPK-dependentGRPendoplasmic reticulum stressGlucose-regulated protein 78cryoprotected rat valve cell autophagytissue viabilitycryoprotectant trehalosecell functionvalve cryopreservation methodscryopreservation approachaortic valve allograft transplantationERS-induced apoptosiscell apoptosisCHOPrat valvesrat valve tissuemiR -221cooling processmiR -32DMSO

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