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The MPEG Effect:  Improving Asymmetric Processes by Simple Additives

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journal contribution
posted on 28.05.2004, 00:00 by Jens Rudolph, Nina Hermanns, Carsten Bolm
Small amounts of simple methoxy poly(ethylene glycol)s (MPEGs) have a beneficial effect on catalyzed asymmetric aryl and alkyl transfer reactions onto aldehydes. The enantiomeric excesses of the products are improved, and this “MPEG effect” allows a reduction of the catalyst loading by a factor of 10.

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