Targeting the endocannabinoid system (DDT 2017).pdf (686.64 kB)

Targeting the endocannabinoid system: future therapeutic strategies

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journal contribution
posted on 2017-05-22, 12:59 authored by Oier Aizpurua-OlaizolaOier Aizpurua-Olaizola, Izaskun Elezgarai, Irantzu Rico-Barrio, Iratxe Zarandona, Nestor Etxebarria, Aresatz Usobiaga
The endocannabinoid system (ECS) is involved in many physiological regulation pathways in the human body, which makes this system the target of many drugs and therapies. In this review, we highlight the latest studies regarding the role of the ECS and the drugs that target it, with a particular
focus on the basis for the discovery of new cannabinoid-based drugs. In addition, we propose some key steps, such as the creation of a cannabinoid–receptor interaction matrix (CRIM) and the use of metabolomics, toward the development of improved and more specific drugs for each relevant disease.