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Tandem Synthesis of 3‑Halo-5-Substituted Isoxazoles from 1‑Copper(I) Alkynes and Dihaloformaldoximes

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posted on 2014-12-05, 00:00 authored by Wenwen Chen, Bo Wang, Nan Liu, Dayun Huang, Xinyan Wang, Yuefei Hu
A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper­(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition and all its drawbacks can now be avoided completely.

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