Synthesis of the C-13 Side Chain
Precursors of the 9-Dihydrotaxane
Analogue ABT-271

Leanna, M. Robert; DeMattei, John A.; Li, Wenke; Nichols, Paul J.; Rasmussen, Michael; Morton, Howard E.

doi:10.1021/ol006508o.s001

Synthesis of the C-13 Side Chain Precursors of the 9-Dihydrotaxane Analogue ABT-271

journal contribution

posted on 2000-10-21, 00:00 authored by M. Robert Leanna, John A. DeMattei, Wenke Li, Paul J. Nichols, Michael Rasmussen, Howard E. Morton

N-Boc-l-Leucinol was converted to two C-13 side chain precursors of the 9-dihydrotaxane analogue ABT-271. The trans-oxazolidine acid 4 and the cis-Boc-lactam 2b were prepared in 44% and 40% overall yield, respectively, and with excellent (>98%) stereochemical purity.