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Synthesis of the Amino Sugar from C-1027

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journal contribution
posted on 2001-06-26, 00:00 authored by M. F. Semmelhack, Yu Jiang, Douglas Ho
The amino sugar side chain (2) from C-1027Chr was synthesized in 12 steps from mannose. The key reactions are an internal displacement by nitrogen to introduce the cis amino group at C-4 and the methylation of an enolate at C-5.