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Synthesis of Hydroxamic Esters via Alkoxyaminocarbonylation of β-Dicarbonyl Compounds

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journal contribution
posted on 1999-07-16, 00:00 authored by Stephen Hanessian, Shawn Johnstone
N-t-Butoxycarbonyl-O-sulfonyl-substituted hydroxylamines react with soft enolates to yield O-t-butoxycarbonylamino derivatives rather than the expected Boc-protected amino acids. The reaction is limited to enolates of β-dicarbonyl compounds. Decarboxylation of the resultant tricarbonyl compound affords malonyl α-alkyl O-t-butoxycarbonylamino derivatives.

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