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Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-Mediated Vinylic Substitution

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journal contribution
posted on 05.04.2000, 00:00 by Ruichao Shen, John A. Porco
A new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides. Modified reaction conditions have been developed to synthesize the O-methyloxime enamide side chains related to the natural products lobatamides A−F, oximidine I and II, and CJ-12 950.