Synthesis of Enamides Related to the
Salicylate Antitumor Macrolides Using
Copper-Mediated Vinylic Substitution

Shen, Ruichao; Porco, John A.

doi:10.1021/ol005800t.s001

Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-Mediated Vinylic Substitution

https://doi.org/10.1021/ol005800t.s001
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journal contribution

posted on 2000-04-05, 00:00 authored by Ruichao Shen, John A. Porco

A new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides. Modified reaction conditions have been developed to synthesize the <i>O</i>-methyloxime enamide side chains related to the natural products lobatamides A−F, oximidine I and II, and CJ-12 950.