Synthesis of Carbapenam Skeletons
Using a Ruthenium-Catalyzed
Cyclization

Mori, Miwako; Kozawa, Yuji; Nishida, Mayumi; Kanamaru, Makiko; Onozuka, Kiyoko; Takimoto, Masanori

doi:10.1021/ol006510f.s001

Synthesis of Carbapenam Skeletons Using a Ruthenium-Catalyzed Cyclization

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posted on 2000-09-13, 00:00 authored by Miwako Mori, Yuji Kozawa, Mayumi Nishida, Makiko Kanamaru, Kiyoko Onozuka, Masanori Takimoto

Carbapenam is a very important skeleton of β-lactam antibiotics, and it has a highly strained structure. When enynes 9 were treated with RuH₂CO(PPh₃)₃ (10 mol %) in toluene upon heating, carbapenams 10 were obtained in good yields.

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RuH antibiotic skeleton Cyclization yield Carbapenam Skeletons enynes 9 toluene Synthesi CO carbapenams 10 mol lactam heating

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