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Synthesis of γ-Benzopyranone by TfOH-Promoted Regioselective Cyclization of o-Alkynoylphenols

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journal contribution
posted on 02.09.2011, 00:00 by Masahito Yoshida, Yuta Fujino, Takayuki Doi
Regioselective cyclization of o-alkynoylphenols forming γ-benzopyranones has been demonstrated. Trifluoromethanesulfonic acid (TfOH) induced 6-endo cyclization of o-alkynoylphenols without forming 5-exo cyclized benzofuranone derivatives to provide the corresponding γ-benzopyranones in high yields.