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posted on 2022-01-24, 18:39 authored by Nawar Naseer, Marisa S. Egan, Valeria M. Reyes Ruiz, William P. Scott, Emma N. Hunter, Tabitha Demissie, Isabella Rauch, Igor E. Brodsky, Sunny Shin

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Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication
PLOS PathogensPLOS Pathogens

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deliver virulence factorscytosolic immune sensorst3sss ), termeddetecting t3ss ligandsinvade host cells1 t3ss needle1 t3ss enablessalmonella enterica </2 t3ss facilitatesevade host recognitionnlrp3 inflammasomes detectnlrp3 inflammasomes controlspi )- 1human naip detects1 t3sssalmonella </host cellthree ligandsinfected cells2 t3sss1 activation5 inflammasomessingle naipserovar typhimuriumreplicate intracellularlypathogenicity islandpartially requirednegative pathogenmurine naipsmediates caspaseintracellular survivalinner rodincluding naip1humans encodehuman naiphuman macrophagesfindings revealcombinatorial naipalso activated

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