ppat.1009718.s014.docx (31.37 kB)
Supplemental Materials and Methods.
journal contribution
posted on 2022-01-24, 18:39 authored by Nawar Naseer, Marisa S. Egan, Valeria M. Reyes Ruiz, William P. Scott, Emma N. Hunter, Tabitha Demissie, Isabella Rauch, Igor E. Brodsky, Sunny Shin(DOCX)
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deliver virulence factorscytosolic immune sensorst3sss ), termeddetecting t3ss ligandsinvade host cells1 t3ss needle1 t3ss enablessalmonella enterica 2 t3ss facilitatesevade host recognitionnlrp3 inflammasomes detectnlrp3 inflammasomes controlspi )- 1human naip detects1 t3sssalmonella host cellthree ligandsinfected cells2 t3sss1 activation5 inflammasomessingle naipserovar typhimuriumreplicate intracellularlypathogenicity islandpartially requirednegative pathogenmurine naipsmediates caspaseintracellular survivalinner rodincluding naip1humans encodehuman naiphuman macrophagesfindings revealcombinatorial naipalso activated
