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posted on 2022-01-24, 18:39 authored by Nawar Naseer, Marisa S. Egan, Valeria M. Reyes Ruiz, William P. Scott, Emma N. Hunter, Tabitha Demissie, Isabella Rauch, Igor E. Brodsky, Sunny Shin

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Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication
PLOS PathogensPLOS Pathogens

Categories

  • Medicine
  • Microbiology
  • Cell Biology
  • Environmental Sciences not elsewhere classified
  • Science Policy
  • Immunology
  • Biological Sciences not elsewhere classified
  • Cancer
  • Hematology
  • Infectious Diseases

Keywords

deliver virulence factorscytosolic immune sensorst3sss ), termeddetecting t3ss ligandsinvade host cells1 t3ss needle1 t3ss enablessalmonella enterica </2 t3ss facilitatesevade host recognitionnlrp3 inflammasomes detectnlrp3 inflammasomes controlspi )- 1human naip detects1 t3sssalmonella </host cellthree ligandsinfected cells2 t3sss1 activation5 inflammasomessingle naipserovar typhimuriumreplicate intracellularlypathogenicity islandpartially requirednegative pathogenmurine naipsmediates caspaseintracellular survivalinner rodincluding naip1humans encodehuman naiphuman macrophagesfindings revealcombinatorial naipalso activated

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