pcbi.1011000.s008.docx (15.21 kB)
Download fileSummary of the median fitted values to the dataset across all groupings, when assuming a monophasic killing (fitting a straight line though the data).
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posted on 2023-04-13, 18:53 authored by Antal Martinecz, Martin J. Boeree, Andreas H. Diacon, Rodney Dawson, Colin Hemez, Rob E. Aarnoutse, Pia Abel zur WieschAll the P values reported are corrected for multiple testing with the Benjamini-Hochberg method.
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total drug exposuresputum culture conversionspecifically peak concentrationspeak drug concentrationsdose ranging trialcurrent mechanistic explanationsquick phase followedprolong antibiotic treatmentsslow phase ’optimize rifampicin treatmentseither antibiotic persistencebacterial killing dependsaccelerating bacterial killingheteroresistance antibiotic treatmentsslow phasebacterial killingvitro mechanistic reasonsslower phaselate phasebacterial populationsxlink ">treatment successswitching backrifampicin heteroresistancequantitative agreementoften associatedhigher dosesheterogeneous susceptibilitiesgrowing bodyfindings indicatealso thought
