Structure-based SASA and ΔpKa calculations for mutated Asp, Glu, and Lys.

The box and whisker plots show quartiles, median (central line), and mean (cross). (A) Distributions of predicted Asp (D), Glu (E), and Lys (K) ΔpKas (pkcalc) are shown for instEQ1 and instGE10 mutation data. Limiting thresholds of +/- 3 are applied for ΔpKa values. (B) The ΔpKa data for mutations in panel (A) are replaced with SASA, for the same subsets.

(PDF)