Stereoselective Synthesis of the C1−C13
Fragment of 2,3-Dihydrodorrigocin A

Brazidec, Jean-Yves Le; Gilson, Charles A.; Boehm, Marcus F.

doi:10.1021/jo050942s.s002

Stereoselective Synthesis of the C1−C13 Fragment of 2,3-Dihydrodorrigocin A

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posted on 2005-09-30, 00:00 authored by Jean-Yves Le Brazidec, Charles A. Gilson, Marcus F. Boehm

The first synthesis of the C1−C13 fragment of 2,3-dihydrodorrigocin A has been achieved from 6-bromohexanoic acid in 14 linear steps and an overall yield of 2%. The configurations of the stereogenic centers C8, C9, and C10 have been determined to be the same as for migrastatin.

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stereogenic Stereoselective Synthesis acid Fragment C 10 synthesis fragment migrastatin Dihydrodorrigocin configuration center dihydrodorrigocin bromohexanoic

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CC BY-NC 4.0

Stereoselective Synthesis of the C1−C13 Fragment of 2,3-Dihydrodorrigocin A

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