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Stereoselective Chloroacetate Aldol Reactions:  Syntheses of Acetate Aldol Equivalents and Darzens Glycidic Esters

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journal contribution
posted on 05.08.2004, 00:00 by Arun K. Ghosh, Jae-Hun Kim
Aldol reaction of the Ti-enolate derived from cis-1-tosylamido-2-indanyl chloroacetate with representative aldehydes proceeded in excellent yield and high diastereoselectivities. Removal of chlorine provided alternative access to highly diastereoselective acetate aldol equivalents or the corresponding glycidic ester condensation products.