Sonochemical Synthesis of Hydrophilic Drug Loaded Multifunctional Bovine Serum Albumin Nanocapsules
journal contributionposted on 02.09.2015, 00:00 by Zhanfeng Li, Ting Yang, Chunming Lin, Quanshun Li, Songfeng Liu, Fengzhi Xu, Hongyan Wang, Xuejun Cui
A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.