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Solvent-Free Methallylboration of Ketones Accelerated by tert-Alcohols

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journal contribution
posted on 19.02.2016, 06:53 by Yongda Zhang, Ning Li, Navneet Goyal, Guisheng Li, Heewon Lee, Bruce Z. Lu, Chris H. Senanayake
A solvent- and metal-free process has been developed for the direct methallylboration of ketones employing the stable B-methallylborinane 1, which was accelerated by tertiary alcohols. In the presence of 2.0 equiv of readily available tertiary alcohols such as tert-amyl alcohol, the methallylation products were prepared at room temperature in excellent yields. The salient features of the described process include simple operation, high efficiency, and mild reaction conditions.