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Solid-Phase Synthesis of Bis-2-imidazolidinethiones from Resin-Bound Tripeptides

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journal contribution
posted on 2000-09-19, 00:00 authored by Adel Nefzi, Marc A. Giulianotti, Nhi A. Ong, Richard A. Houghten
The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.

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