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Short and Efficient Route to the Fully Functionalized Polar Core of Scyphostatin

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journal contribution
posted on 26.05.2005, 00:00 by Emmanuel N. Pitsinos, Ana Cruz
Diastereoselective oxidative dearomatization of benzopyran 5 to the corresponding p-quinol 9b allows a fast, efficient, and versatile entry to scyphostatin's polar epoxycyclohexenone moiety as demonstrated by the preparation of its palmitoyl analogue 16 (R = (CH2)14CH3).