Self-Assembly of Functionalized Lipophilic Guanosines into Cation-Free Stacked Guanine-Quartets
journal contributionposted on 2021-07-19, 17:44 authored by Marilena Campitiello, Alessio Cremonini, Marco A. Squillaci, Silvia Pieraccini, Artur Ciesielski, Paolo Samorì, Stefano Masiero
The hierarchical self-assembly of various lipophilic guanosines exposing either a phenyl or a ferrocenyl group in the C(8) position was investigated. In a solution, all the derivatives were found to self-assemble primarily into isolated guanine (G)-quartets. In spite of the apparent similar bulkiness of the two substituents, most of the derivatives form disordered structures in the solid state, whereas a specific 8-phenyl derivative self-assembles into an unprecedented, cation-free stacked G-quartet architecture.