Secondary Metabolites with Agricultural Antagonistic Potentials from Beauveria felina, a Marine-Derived Entomopathogenic Fungus
journal contributionposted on 2020-12-02, 22:13 authored by Feng-Yu Du, Xiao-Ming Li, Ze-Chun Sun, Ling-Hong Meng, Bin-Gui Wang
Soil-borne pathogens and weeds could synergistically affect vegetable growth and result in serious losses. The investigation of antagonistic metabolites from a marine-derived entomopathogenic fungus, Beauveria felina, obtained polyhydroxy steroid (1), tricyclic diterpenoid (2), isaridin (3), and destruxin cyclodepsipeptides (4–6). The structures and absolute configurations of new 1–3 were elucidated by extensive spectroscopic and X-ray crystallographic analyses, as well as electronic circular dichroism (ECD) calculations. Compounds 1 and 2 showed antifungal activities against carbendazim-resistant strains of Botrytis cinerea, with the minimum inhibitory concentration (MIC) values ranging from 16 to 32 μg/mL, which were significantly better than those of carbendazim (MIC = 256 μg/mL). Compound 5 exhibited significant antagonistic activity against the radicle growth of Amaranthus retroflexus seedlings, which was almost identical to that of the positive control (2,4-dichlorophenoxyacetic acid). The structure–activity differences of 4–6 suggested that the Cl atom in HMPA1 and β-Me in Pro2 should be the key factors to their herbicidal activities. Besides, compounds 3–6 showed moderate nematicidal activities against Meloidogyne incognita. These antagonistic effects of 1–6 were first reported and further revealed the synergistically antagonistic potential of B. felina to be developed into the biopesticide.