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Room Temperature, Palladium-Mediated P–Arylation of Secondary Phosphine Oxides

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journal contribution
posted on 07.09.2012, 00:00 by Aaron J. Bloomfield, Seth B. Herzon
We show that a broad range of aryl iodides are efficiently coupled with secondary phosphine oxides using 1 mol % of a catalyst formed in situ from tris(dibenzylideneacetone)dipalladium and Xantphos (1). Scalemic (S)-methylphenylphosphine oxide [(S)-2e] is shown to undergo arylation without detectable stereoerosion. The application of this method to the synthesis of novel P-chiral phosphines and PCP ligands is demonstrated.

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