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Role of Hemilabile Diamine Ligands in the Amine-Directed C–H Borylation of Arenes

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journal contribution
posted on 2015-01-12, 00:00 authored by Lillian V. A. Hale, Kathryn A. McGarry, Marissa A. Ringgold, Timothy B. Clark
A study of the role played by the bidentate ligand used in amine-directed C–H borylation is described. Both reaction conversion and selectivity were significantly impacted when steric congestion and electronic perturbations of the bidentate diamine ligand were made, but a more significant influence was imparted by reducing the bite angle of the ligand. N-Benzylaminopyridine was identified as a general ligand that improves both selectivity and yield for most problematic substrates previously reported with picolylamine as ligand.