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Ricicomin A, a new alkaloid from the leaves of Ricinus communis Linn

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journal contribution
posted on 24.10.2020, 06:50 by Nguyen Kim Tuyen Pham, Thi Thao Linh Tran, Thuc Huy Duong, Nguyen Tien Trung, Dang Cam Tu Phan, Dinh Tri Mai, Van Kieu Nguyen, Bui Linh Chi Huynh, Thi Anh Tuyet Nguyen, Trong Duc Tran, Thi Ngoc Mai Tran, Tan Phat Nguyen

From the leaves of Ricinus communis Linn., one new alkaloid, named ricicomin A (1) together with three known ones, ricinine (2), N-demethylricinine (3) and 4-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]butanoic acid (4) were justified by repeated chromatographic methods. Their structures were determined by comprehensive IR, HR-ESI-MS and NMR analyses. Compound 4 was identified for the first time from the genus Ricinus. DFT-NMR chemical shift calculations and subsequent DP4+ probability methods were applied to confirm the chemical structure of 1. Compounds 1–3 did not display cytotoxic effect against three human cancer cell lines (MCF-7, HepG2 and HeLa) using SRB assay.


This research is funded by Sai Gon University (SGU) under grant number TĐ2020-25.