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Rhodium(III)-Catalyzed Aerobic Oxidative C–H Olefination of Unsaturated Acrylamides with Unactivated Olefins

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journal contribution
posted on 2021-01-19, 15:48 authored by Ravichandran Logeswaran, Masilamani Jeganmohan
A rhodium­(III)-catalyzed aerobic oxidative cross-coupling of acrylamides with unactivated alkenes via vinylic C–H activation has been developed. The present cross-coupling reaction was examined with a variety of differently functionalized acrylamides and unactivated olefins. In these reactions, highly valuable amide-functionalized butadienes were prepared in good to excellent yields. This protocol was also compatible with Weinreb amides. A possible reaction mechanism involving the chelation-assisted vinylic C–H activation via a carboxylate-assisted deprotonation pathway is proposed.