ja7b06829_si_001.pdf (15.79 MB)
Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes
journal contributionposted on 2017-09-20, 00:00 authored by Jianguo Liu, Suppachai Krajangsri, Thishana Singh, Giulia De Seriis, Napasawan Chumnanvej, Haibo Wu, Pher G. Andersson
A highly efficient regio- and enantioselective monohydrogenation of 1,4-dienes has been realized using an iridium catalyst with a chiral N,P-ligand under mild conditions. The substrate scope was studied and included both unfunctionalized as well as functionalized substituents on the meta- or para-position. Substrates having substituents with functionalities such as silyl protected alcohols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98% ee).