ja7b06829_si_001.pdf (15.79 MB)
Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation of 1,4-Dienes
journal contribution
posted on 2017-09-20, 00:00 authored by Jianguo Liu, Suppachai Krajangsri, Thishana Singh, Giulia De Seriis, Napasawan Chumnanvej, Haibo Wu, Pher G. AnderssonA highly
efficient regio- and enantioselective monohydrogenation
of 1,4-dienes has been realized using an iridium catalyst with a chiral
N,P-ligand under mild conditions. The substrate scope was studied
and included both unfunctionalized as well as functionalized substituents
on the meta- or para-position. Substrates
having substituents with functionalities such as silyl protected alcohols
or ketals were monohydrogenated in high regioselectivity and high
enantiomeric excess (up to 98% ee).