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Regioselective Carbene Insertion on Polysubstituted Dihydroaromatic Compounds

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journal contribution
posted on 2006-05-11, 00:00 authored by Gerhard Hilt, Fabrizio Galbiati
The rhodium-catalyzed CH-insertion reaction of diazo ester derivatives into dihydroaromatic compounds was expanded to the application of various polysubstituted and functionalized 1,4-dienes generated from a cobalt-catalyzed Diels−Alder reaction. The highly regioselective CH-insertion process produces after DDQ oxidation polysubstituted, polyfunctionalized aromatic compounds in good overall yields.