jo8b02977_si_001.pdf (2.64 MB)
Reductant-Free Aerobic Hydroxylation of Isoquinoline-1,3(2H,4H)‑dione Derivatives
journal contribution
posted on 2019-01-15, 00:00 authored by Yuanyong Yang, Yingxian Li, Cheng Cheng, Guo Yang, Shuiying Wan, Jiquan Zhang, Yuanhu Mao, Yonglong Zhao, Lin Zhang, Chun Li, Lei TangBase-catalyzed
efficient hydroxylation of isoquinoline-1,3(2H,4H)-diones with air under transition-metal-free
and reductant-free conditions was established. This methodology is
essentially mild and compatible with a broad range of substrates,
including aryl, heteroaryl, and alkyl groups. Also, the product could
be simply transformed into a hydroxylated tetrahydroisoquinoline core
structure through a reductive process.