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Readily Available Phosphine−Phosphoramidite Ligands for Highly Efficient Rh-Catalyzed Enantioselective Hydrogenations

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journal contribution
posted on 2006-09-14, 00:00 authored by Jia-Di Huang, Xiang-Ping Hu, Zheng-Chao Duan, Qing-Hen Zeng, Sai-Bo Yu, Jun Deng, Dao-Yong Wang, Zhuo Zheng
A new family of air- and moisture-stable phosphine−phosphoramidite ligands (PEAPhos) has been prepared from commercially available and inexpensive (S)-α-phenylethylamine through a two- or three-step transformation and successfully applied in the rhodium-catalyzed enantioselective hydrogenations of a variety of substrates, in which up to 99.9% ee was obtained for all of these kinds of substrates.