Post-print: A polymorphism in IL4 associates with sensory neuropathy in African HIV patients. DOI: 10.1016/j.molimm.2013.02.002

Post-print copy of: Wadley AL, Kamerman PR, Chew CSN, Lombard Z, Cherry CL, Price P. A polymorphism in IL4 associates with sensory neuropathy in African HIV patients. Molecular Immunology 55: 197-199, 2013. DOI: 10.1016/j.molimm.2013.02.002, PMID: 23511027

Abstract: Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation.