figshare
Browse
DOCUMENT
Demurtas_et_al_2020.docx (56.13 kB)
DOCUMENT
Demurtas_et_al_2020.pdf (916.82 kB)
1/0
2 files

Physical activity and exercise in mild cognitive impairment and dementia: an umbrella review of intervention and observational studies

journal contribution
posted on 2023-08-30, 17:34 authored by Jacopo Demurtas, Daniel Schoene, Gabriel Torbahn, Alessandra Marengoni, Giulia Grande, Liye Zou, Mirko Petrovic, Stefania Maggi, Matteo Cesari, Sarah Lamb, Pinar Soysal, Wolfgang Kemmler, Cornel Sieber, Christoph Mueller, Susan Shenkin, Lukas Schwingshackl, Lee Smith, Nicola Veronese
Objectives: The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia. Design: Umbrella review of systematic reviews (SR), with or without meta-analyses (MAs), of randomized controlled trials (RCTs) and observational studies. Settings and Participants: People with MCI or dementia, confirmed through validated assessment measures. Any form of physical activity/exercise was included. As controls, we included participants not following any prespecified physical activity/exercise intervention or following the same standard protocol with the intervention group. Methods: The protocol was registered in PROSPERO (CDR 164197). Major databases were searched until December 31, 2019. The certainty of evidence of statistically significant outcomes was evaluated using the Grading of Recommendations Assessment, Development and Evaluation approach. SRs' findings, without a formal MA, were reported descriptively. Results: Among 1160 articles initially evaluated, 27 SRs (all of RCTs, 9 without MA) for a total of 28,205 participants with MCI/dementia were included. In patients with MCI, mind-body intervention (standardized mean difference [SMD] = 0.36; 95% confidence intervals [CI] 0.20–0.52; low certainty) and mixed physical activity interventions (SMD = 0.30; 95% CI 0.11–0.49; moderate certainty) had a small effect on global cognition, whereas resistance training (SMD = 0.80; 95% CI 0.29–1.31; very low certainty) had a large effect on global cognition. In people affected by dementia, physical activity/exercise was effective in improving global cognition in Alzheimer disease (SMD = 1.10; 95% CI 0.65–1.64; very low certainty) and in all types of dementia (SMD = 0.48; 95% CI 0.22–0.74; low certainty). Finally, physical activity/exercise improved noncognitive outcomes in people with dementia including falls, and neuropsychiatric symptoms. Conclusions and Implications: Supported by very low-to-moderate certainty of evidence, physical activity/exercise has a positive effect on several cognitive and noncognitive outcomes in people with MCI and dementia, but RCTs, with low risk of bias/confounding, are still needed to confirm these relationships.

History

Refereed

  • Yes

Volume

21

Issue number

10

Page range

1415-1422

Publication title

Journal of the American Medical Directors Association

ISSN

1538-9375

Publisher

Elsevier

File version

  • Accepted version

Language

  • eng

Legacy posted date

2020-08-24

Legacy creation date

2020-08-24

Legacy Faculty/School/Department

Faculty of Science & Engineering

Usage metrics

    ARU Outputs

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC