Phylogenetic Considerations in the Evolutionary Development of Aminoglycoside Resistance Genes in Pathogenic Bacteria
This study revisits antibiotic resistance as a source of evolutionary development in pathogenic bacteria. By taking a molecular phylogenetic approach to this inquiry, I seek to find homologous correlations in antimicrobial resistance gene families across a broad spectrum of bacteria, as to indentify the possible acquisition of those genes through divergent events in evolutionary context. In order to test this, I examine the various degrees of genetic similarity in two antimicrobial resistance genomic datasets, namely aadA1 & aadA2 aminoglycoside resistance genes, among bacteria that occur in a multitude of environments. Moreover, the results from phylogenetic analysis suggests that pathogenic antibiotic resistance for aadA1 & aadA2 aminoglycoside resistance genes may have been acquired through evolutionary events with a common ancestor of a soil-dwelling bacterium.
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- Plant cell and molecular biology
- Animal cell and molecular biology
- Microbiology not elsewhere classified
- Bioinformatics and computational biology not elsewhere classified
- Bioinformatic methods development
- Other biological sciences not elsewhere classified
- Medical biotechnology not elsewhere classified
- Genetics not elsewhere classified
- Evolutionary biology not elsewhere classified