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Pd-Catalyzed Tandem Cyclization of Ethyl Glyoxalate and Amines: Rapid Assembly of Highly Substituted Cyclic Dehydro-α-Amino Acid Derivatives

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journal contribution
posted on 2012-11-16, 00:00 authored by Yueting Luo, Xiaoxia Lu, Yong Ye, Ya Guo, Huanfeng Jiang, Wei Zeng
A novel cascade cyclization of ethyl glyoxalate and amines proceeds in the presence of Pd(TFA)2 (5 mol %) to give the cyclic dehydro-α-amino acid derivatives. This method provides a fast and simple access to highly substituted dihydro-pyrrol-2-ones in good yields.