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Pd-Catalyzed Enantioselective Dicarbofunctionalization of Alkene to Access Disubstituted Dihydroisoquinolinone

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journal contribution
posted on 2021-05-13, 15:40 authored by Qiaoyu Chen, Sanliang Li, Xiaoxiao Xie, Hao Guo, Junfeng Yang, Junliang Zhang
A Pd/Xu-Phos-catalyzed asymmetric Heck/Suzuki domino reaction has been developed that shows high functional group tolerance and enables coupling with various aryl/alkenyl borates. A series of chiral disubstituted dihydroisoquinolinones could be obtained in good yields and excellent enantioselectivities.