Palladium-Catalyzed Stereoselective Formation of α-O-Glycosides

A novel method for palladium-catalyzed stereoselective formation of α-O-glycosides has been developed. This strategy relies on the palladium−biaryl phosphine catalyst−glycal donor complexation to control the anomeric selectivity. It does not depend on the nature of the protecting groups on the substrates, thus eliminating the need for cumbersome protecting group manipulations.