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Palladium-Catalyzed C(sp2)–H Pyridocarbonylation of N‑Aryl-2-aminopyridines: Dual Function of the Pyridyl Moiety

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journal contribution
posted on 16.05.2014, 00:00 by Dongdong Liang, Yimiao He, Qiang Zhu
An efficient synthesis of 11H-pyrido­[2,1-b]­quinazolin-11-one through palladium-catalyzed C­(sp2)–H pyridocarbonylation of N-aryl-2-amino­pyridines has been developed. The pyridyl group acts as an intramolecular nucleophile for the first time in C–H carbonylation reactions.