Palladium-Catalyzed (4 + 4) Annulation of Silacyclobutanes and 2‑Iodobiarenes to Eight-Membered Silacycles via C–H and C–Si Bond Activation
journal contributionposted on 26.04.2021, 17:35 by Ming-Hui Zhu, Xiao-Wen Zhang, Muhammad Usman, Hengjiang Cong, Wen-Bo Liu
Construction of eight-membered silacycles via Pd-catalyzed (4 + 4) annulation of silacyclobutanes and 2-iodobiphenyl derivatives is described. This strategy involves direct C–H and C–Si bond activation followed by a ring annulation and features low catalyst loading, ligand-free conditions, and readily available starting materials. Mechanistic studies revealed the involvement of five-membered palladacycle species in the reaction.
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ligand-free conditionsAnnulationConstructionPalladium-CatalyzedPd-catalyzedfive-membered palladacycle speciesEight-Membered Silacycles2- iodobiphenyl derivativesActivationstrategyMechanistic studiesmaterialeight-membered silacyclesactivationring annulationinvolvementSilacyclobutaneBondIodobiarenecatalyst loadingsilacyclobutanebond