pone.0269139.s007.pdf (142.91 kB)
Download filePackaging assessment on AAV9 particles by CryoTEM.
journal contribution
posted on 2022-06-03, 17:28 authored by Mathieu Colomb-Delsuc, Roman Raim, Christian Fiedler, Stefan Reuberger, Johannes Lengler, Rickard Nordström, Martin Ryner, Ioana Mihaela Folea, Barbara Kraus, Juan A. Hernandez Bort, Ida-Maria Sintorn(PDF)
History
Usage metrics
Categories
Keywords
transmission electron microscopymarket today stressinghowever shown limitationsfull recombinant adenoessential quality measurementcharacterizing recombinant adenoallows direct visualizationvector capsids appearssmall number approvedgene therapy vectorsalso investigated alongclinical drug trialsanalytical method basednegative stain temestablished characterization methoddrug development processassociated virus particlesassociated virusvector particlesviral vectorsfixed numbercontinuous developmentcomponents investigatedcharacterization methodsintuitive methoddrug candidatesparticles presentparticles containingfilled particlesxlink ">validated accordingrobustly determinesobserved variabilitynaturally seemsich q2critical role
