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Novel Substituted Aminoalkylguanidines as Potential Antihyperglycemic and Food Intake-Reducing Agents

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journal contribution
posted on 2008-06-12, 00:00 authored by Emanuela Tassoni, Fabio Giannessi, Tiziana Brunetti, Pompeo Pessotto, Michela Renzulli, Massimiliano Travagli, Suvi Rajamäki, Samanta Prati, Secondo Dottori, Federico Corelli, Walter Cabri, Paolo Carminati, Maurizio Botta
We report the synthesis and evaluation of aminoalkylguanidine analogues and derivatives in C57BL/KsJ db/db diabetic mice, following identification by random screening of 1a and 1b as potential antihyperglycemics and/or modulators of food intake. These compounds are related to galegine, a γ,γ-dimethylallylguanidine. Between the newly identified compounds, 1h N-(cyclopropylmethyl)-N′-(4-(aminomethyl)cyclohexylmethyl)guanidine showed the most balanced activity as antihyperglycemic and food intake-reducing agent.