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Download fileNew Bactericidal Surgical Suture Coating
journal contribution
posted on 2012-08-21, 00:00 authored by Yan Li, Kushi N. Kumar, Jeffrey M. Dabkowski, Meagan Corrigan, Richard
W. Scott, Klaus Nüsslein, Gregory N. TewThis paper demonstrates the effectiveness of a new antimicrobial
suture coating. An amphiphilic polymer, poly[(aminoethyl methacrylate)-co-(butyl methacrylate)] (PAMBM), inspired by antimicrobial
peptides, was bactericidal against S. aureus in time-kill experiments. PAMBM was then evaluated in a variety
of polymer blends using the Japanese Industrial Standard (JIS) method
and showed excellent antimicrobial activity at a low concentration
(0.5 wt %). Using a similar antimicrobial coating formula to commercial
Vicryl Plus sutures, disk samples of the coating material containing
PAMBM effectively killed bacteria (98% reduction at 0.75 wt %). Triclosan,
the active ingredient in Vicryl Plus coatings, did not kill the bacteria.
Further Kirby-Bauer assays of these disk samples showed an increasing
zone of inhibition with increasing concentration of PAMBM. Finally,
the PAMBM-containing coating was applied to sutures, and the morphology
of the coating surface was characterized by SEM, along with Vicryl
and uncoated sutures. The PAMBM-containing sutures killed bacteria
more effectively (3 log10 reduction at 2.4 wt %) than Vicryl
Plus sutures (0.5 log10 reduction).