N-Heterocyclic Carbene Ligands in
Cobalt-Catalyzed Sequential Cyclization/Cross-Coupling Reactions of
6-Halo-1-hexene Derivatives with
Grignard Reagents

Someya, Hidenori; Ohmiya, Hirohisa; Yorimitsu, Hideki; Oshima, Koichiro

doi:10.1021/ol070392f.s001

ol070392f_si_001.pdf (1.03 MB)

N-Heterocyclic Carbene Ligands in Cobalt-Catalyzed Sequential Cyclization/Cross-Coupling Reactions of 6-Halo-1-hexene Derivatives with Grignard Reagents

journal contribution

posted on 2007-04-12, 00:00 authored by Hidenori Someya, Hirohisa Ohmiya, Hideki Yorimitsu, Koichiro Oshima

N-Heterocyclic carbene/cobalt systems effectively catalyze sequential cyclization/cross-coupling reactions of 6-halo-1-hexene derivatives with trialkylsilylmethyl and 1-alkynyl Grignard reagents, which phosphine and amine ligands did not promote.

N-Heterocyclic Carbene Ligands in Cobalt-Catalyzed Sequential Cyclization/Cross-Coupling Reactions of 6-Halo-1-hexene Derivatives with Grignard Reagents

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