ma0c00374_si_001.pdf (2.18 MB)
Multiblock Copolymers toward Segmentation-Driven Morphological Transition
journal contribution
posted on 2020-07-07, 14:40 authored by Yi Zheng, Chuang Weng, Cheng Cheng, Jinling Zhao, Rui Yang, Qin Zhang, Mingming Ding, Hong Tan, Qiang FuConventional
methods for controlling self-assembly are generally
based on the change in hydrophilic/hydrophobic volume fraction of
diblock or triblock copolymers, which suffer from low structural diversity
and limited chemical tunability. Inspired by nature, segmented multiblock
copolymers (MBCs) offer unparalleled opportunities for engineering
of biomimetic nanomaterials with tailored properties. However, the
self-assembly of MBCs remains largely unexplored and poorly understood.
In this study, we report a segmentation-mediated self-assembly strategy
to manipulate the morphology of protein-mimic responsive MBCs by facilely
altering the block numbers while holding the amphiphilicity constant.
In particular, we found that an increased number of nearly alternating
biodegradable poly(ε-caprolactone) and hydrophilic polyethylene
glycol segments drives micelle-to-worm-to-vesicle transition. Moreover,
the l-cystine residue-enriched interlayer of assemblies enables
a depolymerization-induced morphology reversion, resulting in a redox-hyper-responsive
property and ultrafast intracellular drug release. Both experimental
and computational results provide a new insight into the self-assembly
of macromolecules and propose a convenient approach to the construction
of smart nanoassemblies with controlled architectures.
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chemical tunabilityl-cystine residue-enriched interlayerultrafast intracellular drug releasepolyethylene glycol segments drives...block numbersMBCtriblock copolymersmultiblock copolymersdepolymerization-induced morphology...redox-hyper-responsive propertybiomimetic nanomaterialsSegmentation-Driven Morphological T...Multiblock Copolymerssegmentation-mediated self-assembly...
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