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Metal-Free Visible-Light-Mediated Oxidative Cross-Coupling of Thiols with P(O)H Compounds Using Air as the Oxidant

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journal contribution
posted on 2016-09-13, 12:34 authored by Jian-Guo Sun, Hua Yang, Ping Li, Bo Zhang
Visible light along with 5 mol % of rose bengal catalyzes the direct S–P­(O) coupling between thiols and P­(O)H compounds in the presence of air as the green oxidant. The protocol is operationally simple and amenable to gram-scale synthesis. A variety of S–P­(O) coupling products can be readily prepared in moderate to excellent yields. The reaction features good functional-group tolerance, operational simplicity, and excellent practicality.